Coenzyme Q (CoQ, ubiquinone) is a redox-active lipid produced across all domains of life
that functions in electron transport and oxidative phosphorylation and whose deficiency …

Flavoprotein monooxygenases (FPMOs) are single-or two-component enzymes that
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …

Reductive genome evolution has purged many metabolic pathways from obligate
intracellular Rickettsia (Alphaproteobacteria; Rickettsiaceae). While some aspects of host …

Terpenoids, also known as isoprenoids, are the largest and most diverse class of organic
compounds in nature and are involved in many membrane-associated cellular processes …

Coenzyme Q (CoQ) is a redox lipid that fulfills critical functions in cellular bioenergetics and
homeostasis. CoQ is synthesized by a multi-step pathway that involves several COQ …

The availability of an ever-increasing diversity of prokaryotic genomes and metagenomes
represents a major opportunity to understand and decipher the mechanisms behind the …

Ubiquinone is an important component of the electron transfer chains in proteobacteria and
eukaryotes. The biosynthesis of ubiquinone requires multiple steps, most of which are …

Overexposure to manganese disrupts cellular energy metabolism across species, but the
molecular mechanism underlying manganese toxicity remains enigmatic. Here, we report …

Metabolons are protein assemblies that perform a series of reactions in a metabolic
pathway. However, the general importance and aptitude of metabolons for enzyme catalysis …

Ubiquinone (UQ) is a polyprenylated lipid that is conserved from bacteria to humans and is
crucial to cellular respiration. How the cell orchestrates the efficient synthesis of UQ, which …