We review the transport, synthesis and catabolism of glutathione in the brain as well as its
compartmentation and biochemistry in different brain cells. The major reactions involving …

Introduction: Depending in part on the glutathione: glutathione disulfide ratio, reversible
protein glutathionylation to a mixed disulfide may occur. Reversible glutathionylation is …

Mutations in isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) have been shown to be
present in most World Health Organization grade 2 and grade 3 gliomas in adults. These …

Imbalances in glutamatergic (excitatory) and GABA (inhibitory) signalling within key brain
networks are thought to underlie many brain and mental health disorders, and for this …

Abstract Magnetic Resonance Spectroscopy (MRS) allows for a non-invasive and non-
ionizing determination of in vivo tissue concentrations and metabolic turn-over rates of more …

Ultra-high field proton magnetic resonance spectroscopy (1 HMRS) offers a unique
opportunity to measure the concentration of neurometabolites implicated in psychosis (PSY) …

The levels of several brain metabolites were investigated in the anterior cingulate cortex
(ACC) and posterior cingulate cortex (PCC) in 13 healthy controls (HC) and 13 patients with …

This article focuses on the description of some of the NMR techniques used in the field of
biomedical and pharmaceutical research. Indeed, the NMR method has special …

Metabolic imaging has great clinical potential in cancer because perturbations of
metabolism are common hallmarks of malignant cellular transformation. Novel imaging …

Introduction Diffuse gliomas are incurable malignancies, which undergo inevitable
progression and are associated with seizure in 50–90% of cases. Glutamate has the …