Cellular membranes are formed from a chemically diverse set of lipids present in various
amounts and proportions. A high lipid diversity is universal in eukaryotes and is seen from …

Extracellular vesicles (EVs) mediate cell-to-cell communication via the transfer of
biomolecules locally and systemically between organs. It has been elucidated that the …

To execute their many vital functions, cell membranes are highly organized. Here, we review
how membrane structure shapes signal transduction across membranes. Recent …

Phosphoinositides play a crucial role in regulating many cellular functions, such as actin
dynamics, signaling, intracellular trafficking, membrane dynamics, and cell–matrix adhesion …

Membrane lipids play vital roles in small extracellular vesicle (sEV) biogenesis. However,
the function of various lipids in the biogenesis of sEVs is still poorly understood …

Protein recycling through the endolysosomal system relies on molecular assemblies that
interact with cargo proteins, membranes, and effector molecules. Among them, the …

Membrane protrusion and adhesion to the extracellular matrix, which involves the extension
of actin filaments and formation of adhesion complexes, are the fundamental processes for …

The ε4 allele of the apolipoprotein E gene (APOE4) is a strong genetic risk factor for
Alzheimer's disease (AD) and several other neurodegenerative conditions, including Lewy …

Toll-like receptors (TLRs) are danger-sensing receptors that typically propagate self-limiting
inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or …

The first reported receptor for SARS-CoV-2 on host cells was the angiotensin-converting
enzyme 2 (ACE2). However, the viral spike protein also has an RGD motif, suggesting that …