Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …

Autism spectrum disorder (ASD) is a complex heterogeneous consortium of pervasive
development disorders (PDD) which ranges from atypical autism, autism, and Asperger …

Heterozygous loss-of-function mutations in SHANK2 are associated with autism spectrum
disorder (ASD). We generated cortical neurons from induced pluripotent stem cells derived …

Mice and rats are widely used to explore mechanisms of mammalian social behavior in
health and disease, raising the question whether they actually differ in their social behavior …

Autism spectrum disorders (ASD) are complex conditions that stem from a combination of
genetic, epigenetic and environmental influences during early pre-and postnatal childhood …

In the hippocampus, locations associated with salient features are represented by a
disproportionately large number of neurons, but the cellular and molecular mechanisms …

Genome-wide association studies (GWAS) have reported substantial genomic loci
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …

The laboratory rat has been used for a long time as the model of choice in several
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide …

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are
activated by glutamate in the central nervous system (CNS). Basically, mGluRs contribute to …

Ultrasonic vocalizations (USVs) are used as a phenotypic marker in mouse models of
neuropsychiatric disorders. Nevertheless, current methodologies still require time …