The mechanisms of thin filament assembly and length regulation in muscles
The actin containing tropomyosin and troponin decorated thin filaments form one of the
crucial components of the contractile apparatus in muscles. The thin filaments are organized …
crucial components of the contractile apparatus in muscles. The thin filaments are organized …
The role of leiomodin in actin dynamics: A new road or a secret gate
D Tolkatchev, CC Gregorio, AS Kostyukova - The FEBS journal, 2022 - Wiley Online Library
Leiomodin is an important emerging regulator of thin filaments. As novel molecular, cellular,
animal model, and human data accumulate, the mechanisms of its action become clearer …
animal model, and human data accumulate, the mechanisms of its action become clearer …
[HTML][HTML] Structural basis of membrane skeleton organization in red blood cells
The spectrin-based membrane skeleton is a ubiquitous membrane-associated two-
dimensional cytoskeleton underneath the lipid membrane of metazoan cells. Mutations of …
dimensional cytoskeleton underneath the lipid membrane of metazoan cells. Mutations of …
A nemaline myopathy–linked mutation inhibits the actin-regulatory functions of tropomodulin and leiomodin
LE Schultz, M Colpan, GE Smith Jr… - Proceedings of the …, 2023 - National Acad Sciences
Actin is a highly expressed protein in eukaryotic cells and is essential for numerous cellular
processes. In particular, efficient striated muscle contraction is dependent upon the precise …
processes. In particular, efficient striated muscle contraction is dependent upon the precise …
Exploring protein relative relations in skeletal muscle proteomic analysis for insights into insulin resistance and type 2 diabetes
A Czajkowska, M Czajkowski, L Szczerbinski… - Scientific Reports, 2024 - nature.com
The escalating prevalence of insulin resistance (IR) and type 2 diabetes mellitus (T2D)
underscores the urgent need for improved early detection techniques and effective treatment …
underscores the urgent need for improved early detection techniques and effective treatment …
CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle
The precise assembly of actin-based thin filaments is crucial for muscle contraction.
Dysregulation of actin dynamics at thin filament pointed ends results in skeletal and cardiac …
Dysregulation of actin dynamics at thin filament pointed ends results in skeletal and cardiac …
Lmod2 is necessary for effective skeletal muscle contraction
Muscle contraction is a regulated process driven by the sliding of actin-thin filaments over
myosin-thick filaments. Lmod2 is an actin filament length regulator and essential for life …
myosin-thick filaments. Lmod2 is an actin filament length regulator and essential for life …
LMOD2‐related dilated cardiomyopathy presenting in late infancy
E Lay, MS Azamian, SW Denfield… - American Journal of …, 2022 - Wiley Online Library
Abstract Leiomodin‐2 (LMOD2) is an important regulator of the thin filament length, known to
promote elongation of actin through polymerization at pointed ends. Mice with Lmod2 …
promote elongation of actin through polymerization at pointed ends. Mice with Lmod2 …
Recessive TMOD1 mutation causes childhood cardiomyopathy
Familial cardiomyopathy in pediatric stages is a poorly understood presentation of heart
disease in children that is attributed to pathogenic mutations. Through exome sequencing …
disease in children that is attributed to pathogenic mutations. Through exome sequencing …
[HTML][HTML] Mutual dependence between tropomodulin and tropomyosin in the regulation of sarcomeric actin assembly in Caenorhabditis elegans striated muscle
S Ono, M Lewis, K Ono - European journal of cell biology, 2022 - Elsevier
Tropomodulin and tropomyosin are important components of sarcomeric thin filaments in
striated muscles. Tropomyosin decorates the side of actin filaments and enhances …
striated muscles. Tropomyosin decorates the side of actin filaments and enhances …