Abstract microRNAs are small, noncoding RNA that negatively regulate gene expression.
Since their discovery in 1993, approximately 2500 human mature microRNAs have been …

It is known that DNA is a well-characterized intracellular target but its size and sequential
characteristics make it an elusive target for selective drug action. Binding of low molecular …

MicroRNAs (miRNAs) are a recently discovered category of small RNA molecules that
regulate gene expression at the post-transcriptional level. Accumulating evidence indicates …

This review, divided into three sections, describes the contribution of the chemists'
community to the development and application of triple helix strategy by using artificial …

The second series of flexible shape-modified nucleosides is introduced. The “fleximers”
feature the purine ring systems split into their individual imidazole and pyrimidine …

Triple-helix formation, using Hoogsteen hydrogen bonding of triplex-forming
oligonucleotides, represents an attractive method for sequence-specific recognition of …

Triplex formation with double‐stranded DNA (dsDNA) by oligonucleotides has potential for
applications in attractive technologies such as gene therapy and genetic diagnosis …

Nucleoside analogues have long served as key chemotherapeutic drugs for the treatment of
viral infections and cancers. Problems associated with the development of drug resistance …

A straightforward route to original imidazole-based nucleosides that makes use of an
enzymatic N-transglycosylation step is reported in both the ribo-and deoxyribo-series. To …

Synthetic modified nucleosides designed to pair in unusual ways with natural nucleobases
have many potential applications in biology and biotechnology. This overview lays the …