With the reignited push for manned spaceflight and the development of companies focused
on commercializing spaceflight, increased human ventures into space are inevitable …

A wide range of cell types depend on mechanically induced signals to enable appropriate
physiological responses. The skeleton is particularly dependent on mechanical information …

Primary cilia are sensory organelles that translate extracellular chemical and mechanical
cues into cellular responses. Bone is an exquisitely mechanosensitive organ, and its …

Bone tissue has the capacity to adapt to its functional environment such that its morphology
is “optimized” for the mechanical demand. The adaptive nature of the skeleton poses an …

In this study we report on direct involvement of fluid shear stresses on the osteoblastic
differentiation of marrow stromal cells. Rat bone marrow stromal cells were seeded in 3D …

Mechanical loads are required for optimal bone mass. One mechanism whereby mechanical
loads are transduced into localized cellular signals is strain‐induced fluid flow through …

An impressive range of tissues and cells are regulated by mechanical loading, and this
regulation is central to disease processes such as osteoporosis, atherosclerosis, and …

The P2X 7 nucleotide receptor (P2X 7 R) is an ATP-gated ion channel expressed in many
cell types including osteoblasts and osteocytes. Mice with a null mutation of P2X 7 R have …

Background Understanding how the mechanical microenvironment influences cell fate, and
more importantly, by what molecular mechanisms, will enhance not only the knowledge of …

Preparation, characterization and cellular biocompatibility study of a series of calcium
polyphosphate containing 0–100mol% of Ca2+ replaced by Sr2+ were reported. The …