Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …

Senescence compromises the essential role that the endothelium plays in maintaining
vascular homeostasis, so promoting endothelial dysfunction and the development of age …

Inhibiting the cell-cycle kinases CDK4 and CDK6 results in significant therapeutic effect in
patients with advanced hormone-positive breast cancer. The efficacy of this strategy is …

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) have recently
entered the therapeutic armamentarium of clinical oncologists, and show promising activity …

Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

Uncontrolled cellular proliferation, mediated by dysregulation of the cell-cycle machinery
and activation of cyclin-dependent kinases (CDKs) to promote cell-cycle progression, lies at …

Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report
molecular profiling of 230 resected lung adenocarcinomas using messenger RNA …

Abstract'Cellular senescence', a term originally defining the characteristics of cultured cells
that exceed their replicative limit, has been broadened to describe durable states of …

Abstract Cyclin-dependent kinase (CDK) 4/6 inhibition in combination with endocrine
therapy is the standard-of-care treatment for patients with advanced-stage hormone receptor …

Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report
molecular profiling of 230 resected lung adenocarcinomas using messenger RNA …