Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …

The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …

Oncogenic mutations in KRAS drive common metabolic programmes that facilitate tumour
survival, growth and immune evasion in colorectal carcinoma, non-small-cell lung cancer …

Abstract Changes in mitochondrial morphology are associated with nutrient utilization, but
the precise causalities and the underlying mechanisms remain unknown. Here, using …

Cancer cells consume glucose and secrete lactate in culture. It is unknown whether lactate
contributes to energy metabolism in living tumors. We previously reported that human non …

Metabolic reprogramming and immune escape play a major role in tumorigenesis.
Increasing number of studies have shown that reprogramming of glutamine metabolism is a …

Adoptive T cell therapy (ACT) produces durable responses in some cancer patients;
however, most tumors are refractory to ACT and the molecular mechanisms underlying …

Glutamine is the most abundant circulating amino acid in blood and muscle and is critical for
many fundamental cell functions in cancer cells, including synthesis of metabolites that …

During immune challenge, T lymphocytes engage pathways of anabolic metabolism to
support clonal expansion and the development of effector functions. Here we report a critical …

Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming
in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic …