Despite the advent of new diagnostics, drugs and regimens, tuberculosis (TB) remains a
global public health threat. A significant challenge for TB control efforts has been the …

Global tuberculosis (TB) eradication is undermined by increasing prevalence of emerging
resistance to available drugs, fuelling ongoing demand for more complex diagnostic and …

Tuberculosis (TB) is an infectious disease of global public health importance caused by the
Mycobacterium tuberculosis complex. Despite advances in diagnosis and treatment, this …

Background Nucleic acid amplification tests (NAATs) are widely used to diagnose
tuberculosis (TB), but cannot discriminate live bacilli from dead bacilli. Live bacilli can be …

Diagnostics that more accurately detect and quantify viable Mycobacterium tuberculosis
(Mtb) in the sputum of patients undergoing therapy are needed. Current culture-and …

Not all patients produce sputum, yet most available TB tests use sputum. We investigated
the utility of a novel RNA-based quantitative test, the tuberculosis molecular bacterial load …

Molecular bacterial load assay (MBLA) rapidly quantifies viable Mycobacterium tuberculosis
(Mtb) and may be useful for monitoring treatment response and treatment efficacy. We …

In South Africa, mycobacterial culture is regarded as the gold standard for the detection of
Mycobacterium tuberculosis complex (MTBC) infection in wildlife even though it is regarded …

Rifampin or multidrug-resistant tuberculosis (RR/MDR-TB) treatment has largely transitioned
to regimens free of the injectable aminoglycoside component, despite the drug class' …

Introduction Tuberculosis (TB) is the leading cause of death worldwide from a single
infectious agent. Bacillus Calmette-Guérin (BCG), the only licensed vaccine, provides limited …