One of the most fundamental problems in immunology is the seemingly schizophrenic ability
of the immune system to launch robust immunity against pathogens, while acquiring and …

Dendritic cells (DCs) include a heterogeneous family of professional APCs involved in
initiation of immunity and in immunologic tolerance. Specifically, peripheral tolerance can be …

Abstract Indoleamine 2, 3-dioxygenase (IDO) is an immunosuppressive enzyme that
contributes to tolerance in a number of biological settings. In cancer, IDO activity may help …

Dendritic cells with tolerogenic function (tolDC) have become a promising
immunotherapeutic tool for reinstating immune tolerance in rheumatoid arthritis (RA) and …

Dendritic cells (DCs) have several characteristics that make them an ideal vehicle for tumor
vaccines, and with the first US FDA-approved DC-based vaccine in use for the treatment of …

Tumors create an abnormal state of tolerance toward themselves and their antigens. One
mechanism that might contribute to this tolerance is the immunoregulatory enzyme …

Dendritic cells are professional antigen-presenting cells that maintain immune tolerance to
self-antigens by deleting or controlling the pathogenicity of auto-reactive T-cells. Dendritic …

The current management of autoimmunity involves the administration of immunosuppressive
drugs coupled to symptomatic and functional interventions such as anti-inflammatory …

Autoimmune diseases affect about one in 15 individuals in developed countries and are
characterized by a breakdown in immune tolerance. Current therapeutic approaches against …

The identification of tumor-specific antigens and the immune responses directed against
them has instigated the development of therapies to enhance antitumor immune responses …