The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that predominately
affects women. It is characterised by a broad spectrum of clinical manifestations, however, its …

As its first identified member, Interleukin-12 (IL-12) named a whole family of cytokines. In
response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and …

Systemic lupus erythematosus (SLE) is a very complex disease where multiple
immunological pathways can concur in inducing tissue damage. Cytokines are key …

The footprint of cytokines is evident in almost every biological process, such as
development, as well as the pathogenesis of the different diseases, immune responses to …

Interleukin-27 (IL-27) is a member of the IL-12 family. The gene encoding IL-27 is located at
chromosome 16p11. IL-27 is considered as a heterodimeric cytokine, which consists of …

Circular RNA (circRNA) are novel types of non-coding RNA that may be used as non-
invasive noninvasive biomarkers in clinical plasma samples. However, the role of circRNA in …

Systemic lupus erythematous (SLE) is a chronic heterogeneous multisystem autoimmune
disease characterized by loss of tolerance to self-antigens and production of numerous …

Background Accumulating data have shown that interleukin-27 (IL27) polymorphisms are
linked to the susceptibility of some autoimmune diseases. We assessed whether there was …

Behcet's disease (BD) is a systemic vasculitis, characterized by recurrent oral aphthous,
genital ulcers, ocular lesions, and other organ involvement. Interleukin (IL)-27 with its pro …