Human antibodies for viral infections
JE Crowe Jr - Annual review of immunology, 2022 - annualreviews.org
Antibodies have been used to prevent or treat viral infections since the nineteenth century,
but the full potential to use passive immunization for infectious diseases has yet to be …
but the full potential to use passive immunization for infectious diseases has yet to be …
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
A central goal of HIV-1 vaccine research is the elicitation of antibodies capable of
neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune …
neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune …
The expanding array of HIV broadly neutralizing antibodies
LE McCoy - Retrovirology, 2018 - Springer
A large array of broadly neutralizing antibodies (bnAbs) against HIV have been isolated and
described, particularly in the last decade. This continually expanding array of bnAbs has …
described, particularly in the last decade. This continually expanding array of bnAbs has …
Restriction of HIV-1 escape by a highly broad and potent neutralizing antibody
Broadly neutralizing antibodies (bNAbs) represent a promising approach to prevent and
treat HIV-1 infection. However, viral escape through mutation of the HIV-1 envelope …
treat HIV-1 infection. However, viral escape through mutation of the HIV-1 envelope …
Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning
CE Radford, P Schommers, L Gieselmann… - Cell Host & Microbe, 2023 - cell.com
Understanding the specificities of human serum antibodies that broadly neutralize HIV can
inform prevention and treatment strategies. Here, we describe a deep mutational scanning …
inform prevention and treatment strategies. Here, we describe a deep mutational scanning …
Multi-donor longitudinal antibody repertoire sequencing reveals the existence of public antibody clonotypes in HIV-1 infection
Characterization of single antibody lineages within infected individuals has provided
insights into the development of Env-specific antibodies. However, a systems-level …
insights into the development of Env-specific antibodies. However, a systems-level …
Broad and potent neutralizing antibodies recognize the silent face of the HIV envelope
Broadly neutralizing antibodies (bNAbs) against HIV-1 envelope (Env) inform vaccine
design and are potential therapeutic agents. We identified SF12 and related bNAbs with up …
design and are potential therapeutic agents. We identified SF12 and related bNAbs with up …
Longitudinal analysis reveals early development of three MPER-directed neutralizing antibody lineages from an HIV-1-infected individual
SJ Krebs, YD Kwon, CA Schramm, WH Law… - Immunity, 2019 - cell.com
Lineage-based vaccine design is an attractive approach for eliciting broadly neutralizing
antibodies (bNAbs) against HIV-1. However, most bNAb lineages studied to date have …
antibodies (bNAbs) against HIV-1. However, most bNAb lineages studied to date have …
HIV envelope glycoform heterogeneity and localized diversity govern the initiation and maturation of a V2 apex broadly neutralizing antibody lineage
Understanding how broadly neutralizing antibodies (bnAbs) to HIV envelope (Env) develop
during natural infection can help guide the rational design of an HIV vaccine. Here, we …
during natural infection can help guide the rational design of an HIV vaccine. Here, we …
Dynamics and durability of HIV-1 neutralization are determined by viral replication
P Schommers, DS Kim, M Schlotz, C Kreer… - Nature Medicine, 2023 - nature.com
Human immunodeficiency virus type 1 (HIV-1)-neutralizing antibodies (nAbs) that prevent
infection are the main goal of HIV vaccine discovery. But as no nAb-eliciting vaccines are yet …
infection are the main goal of HIV vaccine discovery. But as no nAb-eliciting vaccines are yet …