The azole antifungal drugs are an important class of chemotherapeutic agents with broad-
spectrum of activity against yeasts and filamentous fungi, act in the ergosterol biosynthetic …

Selective optimization of side activities of drug molecules (the SOSA approach) is an
intelligent and potentially more efficient strategy than HTS for the generation of new …

The renaissance of catalytic metal hydride hydrogen atom transfer (MHAT) offers advanced
tools for radical chemistry on simple olefins. While 3 d transition metals like cobalt, iron and …

A series of novel amine-derived bis-azole compounds were designed by the systematical
structural modification of Fluconazole and synthesized by a convenient and efficient method …

Imidazoles are one of the most promising and vigorously pursued areas of contemporary
antifungal chemotherapy depicting broad spectrum and potent activity. They have relatively …

A general protocol has been developed for the Markovnikov-selective intermolecular
hydrofunctionalization based on visible-light-mediated Co/Ru dual catalysis. The key feature …

1-[(Aryl)(4-aryl-1 H-pyrrol-3-yl) methyl]-1 H-imidazoles were recently reported by our group
as potent anti-Candida agents belonging to the antifungal azole class. In the present paper …

Owing to the growing need for antifungal agents, we synthesized a new series 2-((5-(4-(5-
substituted-1 H-benzimidazol-2-yl) phenyl)-4-substituted-4 H-1, 2, 4-triazol-3-yl) thio)-1 …

Recent research has shown broad antifungal activity of the classic antidepressants selective
serotonin reuptake inhibitors (SSRIs). This fact, combined with the increased cross …

Multicomponent reactions, conducted in a domino, sequential or consecutive fashion, have
not only considerably enhanced synthetic efficiency as one-pot methodology, but they have …