Optical brain imaging has seen 30 years of intense development, and has grown into a rich
and diverse field. In-vivo imaging using light provides unprecedented sensitivity to functional …

This personal recollection looks at the evolution of ideas about the dynamics of the blood
oxygenation level dependent (BOLD) signal, with an emphasis on the balloon model. From …

Light stimulation evokes neuronal activity in the retina, resulting in the dilation of retinal
blood vessels and increased blood flow. This response, named functional hyperemia, brings …

The mechanisms that link a transient neural activity to the corresponding increase of
cerebral blood flow (CBF) are termed neurovascular coupling (NVC). They are possibly …

Brain vasculature is a complex and interconnected network under tight regulatory control
that exists in intimate communication with neurons and glia. Typically, hemodynamics are …

The cortical hemodynamic response to somatosensory stimulus is investigated at the level of
individual vascular compartments using both depth-resolved optical imaging and in-vivo two …

An understanding of the relationship between changes in neural activity and the
accompanying hemodynamic response is crucial for accurate interpretation of functional …

Neuronal activity-induced changes in vascular tone and oxygen consumption result in a
dynamic evolution of blood flow, volume, and oxygenation. Functional neuroimaging …

The BOLD contrast mechanism has a complex relationship with functional brain activity,
oxygen metabolism, and neurovascular factors. Accurate interpretation of the BOLD signal …

In a companion paper (Lorthois et al., Neuroimage, in press), we perform the first simulations
of blood flow in an anatomically accurate large human intra-cortical vascular network …