There is a growing interest in understanding tissue organization, homeostasis, and
inflammation. However, despite an abundance of data, the organizing principles of tissue …

Early atherosclerosis features functional and structural changes in the endothelial barrier
function that affect the traffic of molecules and solutes between the vessel lumen and the …

Increased pulmonary microvessel pressure experienced in left heart failure, head trauma, or
high altitude can lead to endothelial barrier disruption referred to as capillary “stress failure” …

Inflammation is usually analysed from the perspective of tissue-infiltrating leukocytes.
Microvascular endothelial cells at a site of inflammation are both active participants in and …

Intercellular junctions mediate adhesion and communication between adjoining endothelial
and epithelial cells. In the endothelium, junctional complexes comprise tight junctions …

Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high
morbidity and mortality rates. The development of novel therapies for sepsis is critically …

Junctional structures maintain the integrity of the endothelium. Recent studies have shown
that, as well as promoting cell–cell adhesion, junctions might transfer intracellular signals …

Replacement of assumed preoperative deficits, in addition to generous substitution of an
unsubstantiated increased insensible perspiration and third space loss, plays an important …

Substances released by platelets during blood clotting are essential participants in events
that link hemostasis and angiogenesis and ensure adequate wound healing and tissue …

Microvascular endothelial injury and dysfunction during ischemic acute renal failure. The
pathophysiology of ischemic acute renal failure (ARF) appears to involve a complex …