This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

Innate immunity is maintained in part by antigen presenting cells (APCs) including dendritic
cells, macrophages, and B cells. APCs interact with T cells to link innate and adaptive …

Leishmania is a genus of protozoan parasites that are transmitted by the bite of
phlebotomine sandflies and give rise to a range of diseases (collectively known as …

Recent research has provided new insights on the epidemiology, pathology and
immunology of canine leishmaniosis (CanL) and its genetic basis. The prevalence of …

Iron and its homeostasis are intimately tied to the inflammatory response. The adaptation to
iron deficiency, which confers resistance to infection and improves the inflammatory …

Iron holds a central position at the host–pathogen interface because mammalian and
microbial cells have an essential demand for the metal, which is required for many metabolic …

Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single
infectious agent. Recent studies targeting candidate genes and “case-control” association …

During inflammation, proinflammatory macrophages sequester iron as a well known
bacteriostatic mechanism. Alternative activation of macrophages is linked to tissue repair …

Host antimicrobial mechanisms reduce iron availability to pathogens. Iron proteins
influencing the innate immune response include hepcidin, lactoferrin, siderocalin …

Crop diseases threaten food security and sustainable agriculture. Consumption of crops
containing nonessential toxic metals leads to health risks for humans. Therefore, cultivation …