Inflammatory bowel disease (IBD) is a group of chronic disorders of the gastrointestinal tract
comprising Crohn's disease (CD) and ulcerative colitis (UC). Their etiologies are unknown …

The small intestine contains CD4+ CD8αα+ double-positive intraepithelial lymphocytes (DP
IELs), which originate from intestinal CD4+ T cells through down-regulation of the …

The effect of alterations in intestinal microbiota on microbial metabolites and on disease
processes such as graft-versus-host disease (GVHD) is not known. Here we carried out an …

Mucosal innate lymphoid cell (ILC) subsets promote immune responses to pathogens by
producing distinct signature cytokines in response to changes in the cytokine …

Coeliac disease is a complex, polygenic inflammatory enteropathy caused by exposure to
dietary gluten that occurs in a subset of genetically susceptible individuals who express …

Many tumors produce platelet-derived growth factor (PDGF)-DD, which promotes cellular
proliferation, epithelial-mesenchymal transition, stromal reaction, and angiogenesis through …

Nutritional supplementation with probiotics can prevent pathologic bone loss. Here we
examined the impact of supplementation with Lactobacillus rhamnosus GG (LGG) on bone …

Complex interactions between host immunity and the microbiome regulate norovirus
infection. However, the mechanism of host immune promotion of enteric virus infection …

Low-grade intestinal inflammation and alterations of gut barrier integrity are found in patients
affected by extraintestinal autoimmune diseases such as type 1 diabetes (T1D), but a direct …

The active form of vitamin D [1, 25-dihydroxycholecalciferol, 1, 25 (OH) 2 D 3] and the
vitamin D receptor (VDR) regulate susceptibility to experimental colitis. The effect of the …