CXCR4-directed theranostics in oncology and inflammation

M Kircher, P Herhaus, M Schottelius, AK Buck… - Annals of nuclear …, 2018 - Springer
Given its prominent role in inflammation and cancer biology, the CXC motif chemokine
receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a …

Imaging inflammation with positron emission tomography

J Iking, M Staniszewska, L Kessler, JM Klose… - Biomedicines, 2021 - mdpi.com
The impact of inflammation on the outcome of many medical conditions such as
cardiovascular diseases, neurological disorders, infections, cancer, and autoimmune …

In vivo targeting of CXCR4—new horizons

M Schottelius, K Herrmann, C Lapa - Cancers, 2021 - mdpi.com
Simple Summary Beyond its pre-eminent role in the context of tumor cell growth as well as
metastasis, the CXC motif chemokine receptor 4 (CXCR4) is a key player in the …

[HTML][HTML] A new class of PentixaFor-and PentixaTher-based theranostic agents with enhanced CXCR4-targeting efficiency

T Osl, A Schmidt, M Schwaiger, M Schottelius… - Theranostics, 2020 - ncbi.nlm.nih.gov
Non-invasive PET imaging of CXCR4 expression in cancer and inflammation as well as
CXCR4-targeted radioligand therapy (RLT) have recently found their way into clinical …

Radiotracer development for bacterial imaging

F Mota, AA Ordonez, G Firth… - Journal of medicinal …, 2020 - ACS Publications
Bacterial infections remain a major threat to humanity and are a leading cause of death and
disability. Antimicrobial resistance has been declared as one of the top ten threats to human …

Advances in PET Imaging of the CXCR4 Receptor:[68Ga] Ga-PentixaFor

L Lindenberg, M Ahlman, F Lin, E Mena… - Seminars in Nuclear …, 2023 - Elsevier
[68 Ga] Ga-PentixaFor, a PET agent targeting CXCR4 is emerging as a versatile radiotracer
with promising applications in oncology, cardiology and inflammatory disease. Preclinical …

[99mTc]Tc-PentixaTec: development, extensive pre-clinical evaluation, and first human experience

M Konrad, A Rinscheid, G Wienand, B Nittbaur… - European Journal of …, 2023 - Springer
Purpose The clinical success non-invasive imaging of CXCR4 expression using [68 Ga] Ga-
PentixaFor-PET warrants an expansion of the targeting concept towards conventional …

Vascular graft infection imaging

E Arnon-Sheleg, Z Keidar - Seminars in Nuclear Medicine, 2023 - Elsevier
Vascular graft infection is a rare, life threatening complication of vascular repair with
synthetic or native material. The pathogenesis, causative microorganisms and clinical …

68Ga-pentixafor PET/MRI for treatment response assessment in mantle cell lymphoma: comparison between changes in lesion CXCR4 expression on PET and lesion …

ME Mayerhoefer, M Raderer, M Weber… - Clinical Nuclear …, 2023 - journals.lww.com
68Ga-Pentixafor PET/MRI for Treatment Response Assessment in... : Clinical Nuclear Medicine
68Ga-Pentixafor PET/MRI for Treatment Response Assessment in Mantle Cell Lymphoma …

In vivo validation of 68Ga-labeled AMD3100 conjugates for PET imaging of CXCR4

I Renard, J Domarkas, S Poty, BP Burke… - Nuclear Medicine and …, 2023 - Elsevier
Introduction The chemokine receptor CXCR4 has been shown to be over-expressed in
multiple types of cancer and is usually associated with aggressive phenotypes and poor …