The hepatocyte nuclear factors (HNFs) namely HNF1α/β, FOXA1/2/3, HNF4α/γ and
ONECUT1/2 are expressed in a variety of tissues and organs, including the liver, pancreas …

The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by
abnormally high blood glucose resulting from a relative deficiency of insulin1. It affects about …

The numerous functions of the liver are controlled primarily at the transcriptional level by the
concerted actions of a limited number of hepatocyte-enriched transcription factors …

II. Nuclear Receptors: General Concepts A. Anatomy of nuclear receptors B. Mechanisms of
action III. Orphan Nuclear Receptors A. Definition

Hepatocyte nuclear factor 4α (HNF4α) plays a critical role in regulating the expression of
many genes essential for normal functioning of liver, gut, kidney, and pancreatic islets. A …

The specialized endocrine and exocrine cells of the pancreas originally derive from a pool of
apparently identical cells in the early gut endoderm. Serial changes in their gene expression …

Objectives: To characterize mesenchymal stem cell‐like cells isolated from human amniotic
fluid for a new source of therapeutic cells. Materials: Fibroblastoid‐type cells obtained from …

All life forms on earth require a continuous input and monitoring of carbon and energy
supplies. The AMP‐activated kinase (AMPK)/sucrose nonfermenting1 (SNF1)/Snf1‐related …

Abstract The 2.7 Å X-ray crystal structure of the HNF4γ ligand binding domain (LBD)
revealed the presence of a fatty acid within the pocket, with the AF2 helix in a conformation …