Vascular endothelial cells and innate immunity

Y Shao, J Saredy, WY Yang, Y Sun, Y Lu… - … , and vascular biology, 2020 - Am Heart Assoc
In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …

Animal models of atherosclerosis–supportive notes and tricks of the trade

A Gisterå, DFJ Ketelhuth, SG Malin… - Circulation …, 2022 - Am Heart Assoc
Atherosclerotic cardiovascular disease is a major cause of death among humans. Animal
models have shown that cholesterol and inflammation are causatively involved in the …

Effects of fatty acids on T cell function: role in atherosclerosis

NA Reilly, E Lutgens, J Kuiper, BT Heijmans… - Nature Reviews …, 2021 - nature.com
T cells are among the most common cell types present in atherosclerotic plaques and are
increasingly being recognized as a central mediator in atherosclerosis development and …

Mitochondrial dysfunction in vascular wall cells and its role in atherosclerosis

D Salnikova, V Orekhova, A Grechko… - International Journal of …, 2021 - mdpi.com
Altered mitochondrial function is currently recognized as an important factor in
atherosclerosis initiation and progression. Mitochondrial dysfunction can be caused by …

Novel insights and current evidence for mechanisms of atherosclerosis: mitochondrial dynamics as a potential therapeutic target

D Li, S Yang, Y Xing, L Pan, R Zhao, Y Zhao… - Frontiers in Cell and …, 2021 - frontiersin.org
Cardiovascular disease (CVD) is the main cause of death worldwide. Atherosclerosis is the
underlying pathological basis of CVD. Mitochondrial homeostasis is maintained through the …

IL-38 in modulating hyperlipidemia and its related cardiovascular diseases

M Lai, H Peng, X Wu, X Chen, B Wang, X Su - International …, 2022 - Elsevier
Hyperlipidemia is confirmed to be associated with several health problems that include the
combination of diabetes mellitus, obesity, and hypertension, ie, metabolic syndrome …

Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans

R Baumgartner, M Berg, L Matic… - Journal of Internal …, 2021 - Wiley Online Library
Background The metabolism of tryptophan (Trp) along the kynurenine pathway has been
shown to carry strong immunoregulatory properties. Several experimental studies indicate …

Chia (Salvia hispanica L.) Seed Total Protein and Protein Fractions Digests Reduce Biomarkers of Inflammation and Atherosclerosis in Macrophages In Vitro

M Grancieri, HSD Martino… - Molecular nutrition & …, 2019 - Wiley Online Library
Scope The objectives are to evaluate the anti‐inflammatory and anti‐atherosclerotic effects
of digested total protein and digested protein fractions from chia seed in macrophages in …

Quantification of atherosclerosis in mice

M Centa, DFJ Ketelhuth, S Malin, A Gisterå - JoVE (Journal of Visualized …, 2019 - jove.com
Cardiovascular disease is the main cause of death in the world. The underlying cause in
most cases is atherosclerosis, which is in part a chronic inflammatory disease. Experimental …

Immunomodulatory effects of drugs for effective cancer immunotherapy

M Matsushita, M Kawaguchi - Journal of oncology, 2018 - Wiley Online Library
Recent advances in cancer immunotherapy, including immune checkpoint inhibitors or
adoptive T cell therapies, have contributed to better outcomes in cancer patients. However …