Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations

H Zhu, D Bi, Y Zhang, C Kong, J Du, X Wu… - Signal transduction and …, 2022 - nature.com
The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …

Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: integration of the glutamate/GABA-glutamine cycle

JV Andersen, A Schousboe, A Verkhratsky - Progress in neurobiology, 2022 - Elsevier
Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Effects of ketone bodies on brain metabolism and function in neurodegenerative diseases

NJ Jensen, HZ Wodschow, M Nilsson… - International journal of …, 2020 - mdpi.com
Under normal physiological conditions the brain primarily utilizes glucose for ATP
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

DA Butterfield, B Halliwell - Nature Reviews Neuroscience, 2019 - nature.com
Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully
understand AD aetiology and pathogenesis, but oxidative damage is a key component. The …

[HTML][HTML] The effects of intermittent fasting on brain and cognitive function

J Gudden, A Arias Vasquez, M Bloemendaal - Nutrients, 2021 - mdpi.com
The importance of diet and the gut-brain axis for brain health and cognitive function is
increasingly acknowledged. Dietary interventions are tested for their potential to prevent …

Cognitive symptoms of Alzheimer's disease: clinical management and prevention

E Joe, JM Ringman - bmj, 2019 - bmj.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
accumulation of amyloid β in the form of extracellular plaques and by intracellular …

[HTML][HTML] Effect of medium chain fatty acid in human health and disease

PG Roopashree, SS Shetty, NS Kumari - Journal of Functional Foods, 2021 - Elsevier
Medium chain fatty acids (MCFAs) has unique transport system and is rapidly metabolized in
the body. It mainly occurs in coconut oil, palm kernel oil and milk products. Dietary …

[HTML][HTML] Ketogenic diet in Alzheimer's disease

M Rusek, R Pluta, M Ułamek-Kozioł… - International journal of …, 2019 - mdpi.com
At present, the prevalence of Alzheimer's disease, a devastating neurodegenerative
disorder, is increasing. Although the mechanism of the underlying pathology is not fully …

Regulation of cerebral blood flow and metabolism during exercise

KJ Smith, PN Ainslie - Experimental physiology, 2017 - Wiley Online Library
New Findings What is the topic of this review? The manuscript collectively combines the
experimental observations from> 100 publications focusing on the regulation of cerebral …

Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of …

M Caprio, M Infante, E Moriconi, A Armani… - Journal of …, 2019 - Springer
Background Weight loss is a milestone in the prevention of chronic diseases associated with
high morbility and mortality in industrialized countries. Very-low calorie ketogenic diets …