Down syndrome is the most common form of intellectual disability and results from one of the
most complex genetic perturbations that is compatible with survival, trisomy 21. The study of …

This chapter reviews the neurological phenotype of Down syndrome (DS) in early
development, childhood, and aging. Neuroanatomic abnormalities in DS are manifested as …

The fungus Candida albicans is an opportunistic pathogen that can exploit imbalances in
microbiome composition to invade its human host, causing pathologies ranging from vaginal …

Scope Trisomy for human chromosome 21 results in D own syndrome (DS), which is among
the most complex genetic perturbations leading to intellectual disability. Accumulating data …

The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …

Down syndrome (DS) is the most common genetic cause of mental disability. Based on the
homology of Hsa21 and the murine chromosomes Mmu16, Mmu17 and Mmu10, several …

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a member of an
evolutionarily conserved family of protein kinases that belongs to the CMGC group of …

The protein kinase DYRK1A has been suggested to act as one of the intracellular regulators
contributing to neurological alterations found in individuals with Down syndrome. For an …

Alternative splicing of tau exon 10 generates tau isoforms with three or four microtubule-
binding repeats, 3R-tau and 4R-tau, which is equally expressed in adult human brain …

Intellectual disability is the unavoidable hallmark of Down syndrome (DS), with a heavy
impact on public health. Reduced neurogenesis and impaired neuron maturation are …