[HTML][HTML] Liver fat scores for noninvasive diagnosis and monitoring of nonalcoholic fatty liver disease in epidemiological and clinical studies

M Reinshagen, S Kabisch, AFH Pfeiffer… - Journal of Clinical and …, 2023 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is strongly associated with the metabolic syndrome
and type 2 diabetes and independently contributes to long-term complications. Being often …

The elusive cephalic phase insulin response: triggers, mechanisms, and functions

W Langhans, AG Watts, AC Spector - Physiological reviews, 2023 - journals.physiology.org
The cephalic phase insulin response (CPIR) is classically defined as a head receptor-
induced early release of insulin during eating that precedes a postabsorptive rise in blood …

Do oscillations in pancreatic islets require pacemaker cells?

BE Peercy, AS Sherman - Journal of Biosciences, 2022 - Springer
The pancreatic islets of Langerhans are biomedically important because they are home to
the beta cells that secrete insulin and are hence important for understanding diabetes. They …

Pulsatile basal insulin secretion is driven by glycolytic oscillations

PA Fletcher, I Marinelli, R Bertram, LS Satin… - …, 2022 - journals.physiology.org
In fasted and fed states, blood insulin levels are oscillatory. While this phenomenon is well
studied at high glucose levels, comparatively little is known about its origin under basal …

Physiologic insulin resensitization as a treatment modality for insulin resistance pathophysiology

F Greenway, B Loveridge, RM Grimes… - International journal of …, 2022 - mdpi.com
Prevalence of type 2 diabetes increased from 2.5% of the US population in 1990 to 10.5% in
2018. This creates a major public health problem, due to increases in long-term …

Dysregulation of β-cell proliferation in diabetes: possibilities of combination therapy in the development of a comprehensive treatment

N Eguchi, AJ Toribio, M Alexander, I Xu, DL Whaley… - Biomedicines, 2022 - mdpi.com
Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia as a
result of insufficient insulin levels and/or impaired function as a result of autoimmune …

Symbiosis of electrical and metabolic oscillations in pancreatic β-cells

I Marinelli, PA Fletcher, AS Sherman, LS Satin… - Frontiers in …, 2021 - frontiersin.org
Insulin is secreted in a pulsatile pattern, with important physiological ramifications. In
pancreatic β-cells, which are the cells that synthesize insulin, insulin exocytosis is elicited by …

The effect of insulin‐loaded gold and carboxymethyl chitosan nanoparticles on gene expression of glucokinase and pyruvate kinase in rats with diabetes type 1

EM Shaaban, DE Ellakwa, NM Elaraby… - Journal of Food …, 2022 - Wiley Online Library
The goal of this study was to see how effective subcutaneous (SC) insulin is and two
different types of oral insulin‐loaded nanoparticles (INS) including carboxymethyl chitosan …

Visually controlled pulsatile release of insulin from chitosan poly-acrylic acid nanobubbles triggered by focused ultrasound

X Yi, Y Luo, Q Zhou, J Wang, Z Yang - International Journal of …, 2023 - Elsevier
Insulin therapy is the most effective way to control the blood glucose value of diabetic
patients. The most effective administration route for insulin is subcutaneous injection …

Role of Oxidative Stress and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in Nonalcoholic Fatty Liver Disease

P Memaj, Z Ouzerara, FR Jornayvaz - International Journal of Molecular …, 2023 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) has become a widely studied subject due to its
increasing prevalence and links to diseases such as type 2 diabetes and obesity. It has …