The ability to directly reprogram mature cells to alternative fates challenges concepts of how
cell identities are maintained, erased, and acquired. Recent advances in understanding and …

Neurodegenerative diseases are characterized by a gradual loss of cognitive and physical
functions. Medications for these disorders are limited and treat the symptoms only. There are …

Serotonergic (5HT) neurons exert diverse and widespread functions in the brain.
Dysfunction of the serotonergic system gives rise to a variety of mental illnesses including …

Direct reprogramming of fibroblasts to neurons induces widespread cellular and
transcriptional reconfiguration. Here, we characterized global epigenomic changes during …

Epigenetic reprogramming of adult human somatic cells to alternative fates, such as the
conversion of human skin fibroblasts to induced pluripotency stem cells (iPSC), has enabled …

Motor symptoms that define Parkinson's disease (PD) are caused by the selective loss of
nigral dopaminergic (DA) neurons. Cell replacement therapy for PD has been focused on …

Recent findings show that human fibroblasts can be directly programmed into functional
neurons without passing via a proliferative stem cell intermediate. These findings open up …

Cellular differentiation processes during normal embryonic development are guided by
extracellular soluble factors such as morphogen gradients and cell contact signals …

The study and treatment of neurological disorders have been hampered by a lack of access
to live, healthy, or disease-affected human neurons. The recent advances in the field of cell …

Technologies for deriving human neurons in vitro have transformed our ability to study
cellular and molecular components of human neurotransmission. Three groups, including …