Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

Protein post-translational modifications (PTMs), which are usually enzymatically catalyzed,
are major regulators of protein activity and involved in almost all celluar processes …

Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely
neural precursor cell expressed developmentally downregulated protein 8 (NEDD8). Here …

Abnormal neddylation activation is frequently observed in human cancers and neddylation
inhibition has been proposed as a therapy for cancer. Here, we report that MLN4924, a …

SIPR α on macrophages binds with CD47 to resist proengulfment signals, but how the
downstream signal of SIPR α controls tumor-infiltrating macrophages (TIMs) is still poorly …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Post-translational modifications of proteins ensure optimized cellular processes, including
proteostasis, regulated signaling, cell survival, and stress adaptation to maintain a balanced …

Small ubiquitin-like modifier (SUMO) typically conjugates to target proteins through
isopeptide linkage to the ε-amino group of lysine residues. This posttranslational …

Developmental down-regulation protein 8 (NEDD8), expressed by neural progenitors, is a
ubiquitin-like protein that conjugates to and regulates the biological function of its substrates …

Neddylation is one type of protein post‐translational modification by conjugating a ubiquitin‐
like protein neural precursor cell‐expressed developmentally downregulated protein 8 to …