The evolution of human genetic and phenotypic variation in Africa

MC Campbell, SA Tishkoff - Current biology, 2010 - cell.com
Africa is the birthplace of modern humans, and is the source of the geographic expansion of
ancestral populations into other regions of the world. Indigenous Africans are characterized …

Genetic variation and adaptation in Africa: implications for human evolution and disease

F Gomez, J Hirbo, SA Tishkoff - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Because modern humans originated in Africa and have adapted to diverse environments,
African populations have high levels of genetic and phenotypic diversity. Thus, genomic …

Ethiopian genetic diversity reveals linguistic stratification and complex influences on the Ethiopian gene pool

L Pagani, T Kivisild, A Tarekegn, R Ekong… - The American journal of …, 2012 - cell.com
Humans and their ancestors have traversed the Ethiopian landscape for millions of years,
and present-day Ethiopians show great cultural, linguistic, and historical diversity, which …

The first modern human dispersals across Africa

T Rito, MB Richards, V Fernandes, F Alshamali… - PloS one, 2013 - journals.plos.org
The emergence of more refined chronologies for climate change and archaeology in
prehistoric Africa, and for the evolution of human mitochondrial DNA (mtDNA), now make it …

Evidence of the interplay of genetics and culture in Ethiopia

S López, A Tarekegn, G Band, L van Dorp… - Nature …, 2021 - nature.com
The rich linguistic, ethnic and cultural diversity of Ethiopia provides an unprecedented
opportunity to understand the level to which cultural factors correlate with–and shape …

Immunogenetics as a tool in anthropological studies

A Sanchez‐Mazas, M Fernandez‐Viña… - …, 2011 - Wiley Online Library
The genes coding for the main molecules involved in the human immune system–
immunoglobulins, human leucocyte antigen (HLA) molecules and killer‐cell immunoglobulin …

Variations in hypertension awareness, treatment, and control among Ghanaian migrants living in Amsterdam, Berlin, London, and nonmigrant Ghanaians living in …

C Agyemang, G Nyaaba, E Beune, K Meeks… - Journal of …, 2018 - journals.lww.com
Objectives: Hypertension is a major burden among African migrants, but the extent of the
differences in prevalence, treatment, and control among similar African migrants and …

Mapping human dispersals into the Horn of Africa from Arabian Ice Age refugia using mitogenomes

F Gandini, A Achilli, M Pala, M Bodner, S Brandini… - Scientific Reports, 2016 - nature.com
Rare mitochondrial lineages with relict distributions can sometimes be disproportionately
informative about deep events in human prehistory. We have studied one such lineage …

The HLA‐B landscape of Africa: signatures of pathogen‐driven selection and molecular identification of candidate alleles to malaria protection

A Sanchez‐Mazas, V Černý, D Di, S Buhler… - Molecular …, 2017 - Wiley Online Library
Human leukocyte antigen (HLA) genes play a key role in the immune response to infectious
diseases, some of which are highly prevalent in specific environments, like malaria in sub …

60,000 years of interactions between Central and Eastern Africa documented by major African mitochondrial haplogroup L2

M Silva, F Alshamali, P Silva, C Carrilho, F Mandlate… - Scientific reports, 2015 - nature.com
Abstract Mitochondrial DNA (mtDNA) haplogroup L2 originated in Western Africa but is
nowadays spread across the entire continent. L2 movements were previously postulated to …