Growing evidence has established two major types of vulvar intraepithelial neoplasia (VIN),
which correspond to two distinct oncogenic pathways to vulvar squamous cell carcinoma …

Vulvar squamous cell carcinoma (VSCC) accounts for> 90% of the malignant tumours of the
vulva. Most VSCC s originate in intraepithelial lesions, named vulvar intraepithelial …

The recent literature has shown that vulvar squamous cell carcinoma (VSCC) can be
stratified into two prognostically relevant groups based on human papillomavirus (HPV) …

Vulval squamous cell carcinoma (VSCC) can arise through two distinct pathways [human
papillomavirus (HPV)‐associated and HPV‐independent], and these VSCC variants are …

Two separate pathways leading to vulvar carcinoma have been suggested. First, a human
papillomavirus (HPV)-dependent pathway, in which premalignant stages of vulvar cancer …

Abstract p16 is a cyclin-dependent kinase-4 inhibitor that is expressed in a limited range of
normal tissues and tumors. In recent years, immunohistochemistry with p16 antibodies has …

Objective The aim of the study was to describe the features required for diagnosis of
differentiated vulvar intraepithelial neoplasia (dVIN) and vulvar aberrant maturation (VAM) …

Background Vulvar squamous cell carcinoma (VSCC) is a rare malignancy of the female
genital tract. We aimed to determine the mucosal high-risk human papillomavirus (HPV) …

Two types of vulvar squamous cell carcinomas (VSCCs) are recognized according to their
relationship to human papillomavirus (HPV). Basaloid or warty carcinomas are considered …

Background The incidence of vulvar squamous cell carcinoma (VSCC) has been on the rise
since the 1990s. There has been no new treatment for advanced and recurrent disease in …