[HTML][HTML] TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

TRPC channels: Structure, function, regulation and recent advances in small molecular probes

H Wang, X Cheng, J Tian, Y Xiao, T Tian, F Xu… - Pharmacology & …, 2020 - Elsevier
Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …

[HTML][HTML] Transient receptor potential canonical (TRPC) channels: then and now

X Chen, G Sooch, IS Demaree, FA White, AG Obukhov - Cells, 2020 - mdpi.com
Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …

A high signal-to-noise Ca2+ probe composed of a single green fluorescent protein

J Nakai, M Ohkura, K Imoto - Nature biotechnology, 2001 - nature.com
Recently, several groups have developed green fluorescent protein (GFP)-based Ca 2+
probes. When applied in cells, however, these probes are difficult to use because of a low …

An introduction to TRP channels

IS Ramsey, M Delling, DE Clapham - Annu. Rev. Physiol., 2006 - annualreviews.org
▪ Abstract The aim of this review is to provide a basic framework for understanding the
function of mammalian transient receptor potential (TRP) channels, particularly as they have …

International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family

LJ Wu, TB Sweet, DE Clapham - Pharmacological reviews, 2010 - ASPET
Transient receptor potential (TRP) channels are a large family of ion channel proteins,
surpassed in number in mammals only by voltage-gated potassium channels. TRP channels …

Phosphoinositides regulate ion channels

B Hille, EJ Dickson, M Kruse, O Vivas… - Biochimica Et Biophysica …, 2015 - Elsevier
Phosphoinositides serve as signature motifs for different cellular membranes and often are
required for the function of membrane proteins. Here, we summarize clear evidence …

The TRP ion channel family

DE Clapham, LW Runnels, C Strübing - Nature Reviews Neuroscience, 2001 - nature.com
Mammalian homologues of the Drosophila transient receptor potential (TRP) channel gene
encode a family of at least 20 ion channel proteins. They are widely distributed in …

Structure of the receptor-activated human TRPC6 and TRPC3 ion channels

Q Tang, W Guo, L Zheng, JX Wu, M Liu, X Zhou… - Cell research, 2018 - nature.com
TRPC6 and TRPC3 are receptor-activated nonselective cation channels that belong to the
family of canonical transient receptor potential (TRPC) channels. They are activated by …

The TRP superfamily of cation channels

C Montell - Science's STKE, 2005 - science.org
The transient receptor potential (TRP) protein superfamily consists of a diverse group of
cation channels that bear structural similarities to Drosophila TRP. TRP channels play …