The changing demographic pattern of multiple sclerosis epidemiology

N Koch-Henriksen, PS Sørensen - The Lancet Neurology, 2010 - thelancet.com
The uneven distribution of multiple sclerosis (MS) across populations can be attributed to
differences in genes and the environment and their interaction. Prevalence and incidence …

Nutrition facts in multiple sclerosis

P Riccio, R Rossano - ASN neuro, 2015 - journals.sagepub.com
The question whether dietary habits and lifestyle have influence on the course of multiple
sclerosis (MS) is still a matter of debate, and at present, MS therapy is not associated with …

Vitamin D: an evidence-based review

T Kulie, A Groff, J Redmer… - The Journal of the …, 2009 - Am Board Family Med
Vitamin D is a fat-soluble vitamin that plays an important role in bone metabolism and seems
to have some anti-inflammatory and immune-modulating properties. In addition, recent …

Immunomodulatory effects of Vitamin D in multiple sclerosis

J Correale, MC Ysrraelit, MI Gaitán - Brain, 2009 - academic.oup.com
Although Vitamin D is best known as a modulator of calcium homeostasis, it also has
immune modulating potential. A protective effect of Vitamin D on multiple sclerosis is …

Vitamin D and neurological diseases: an endocrine view

C Di Somma, E Scarano, L Barrea… - International journal of …, 2017 - mdpi.com
Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and
receptors involved in genomic and non-genomic effects. In addition to classical bone-related …

Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D

SV Ramagopalan, NJ Maugeri, L Handunnetthi… - PLoS …, 2009 - journals.plos.org
Multiple sclerosis (MS) is a complex trait in which allelic variation in the MHC class II region
exerts the single strongest effect on genetic risk. Epidemiological data in MS provide strong …

The role of vitamins in neurodegenerative disease: An update

SN Rai, P Singh, HWM Steinbusch, E Vamanu… - Biomedicines, 2021 - mdpi.com
Acquiring the recommended daily allowance of vitamins is crucial for maintaining
homeostatic balance in humans and other animals. A deficiency in or dysregulation of …

Vitamin D as a protective factor in multiple sclerosis

J Salzer, G Hallmans, M Nyström, H Stenlund… - Neurology, 2012 - AAN Enterprises
Objective: To examine the association between 25-hydroxyvitamin D (25 [OH] D) levels and
the risk of multiple sclerosis (MS) in blood samples collected prospectively and during …

A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis

JM Burton, S Kimball, R Vieth, A Bar-Or, HM Dosch… - Neurology, 2010 - AAN Enterprises
Objective: Low vitamin D status has been associated with multiple sclerosis (MS) prevalence
and risk, but the therapeutic potential of vitamin D in established MS has not been explored …

Environmental risk factors for multiple sclerosis: a review with a focus on molecular mechanisms

C O'Gorman, R Lucas, B Taylor - International journal of molecular …, 2012 - mdpi.com
Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system
commonly affecting young adults. Pathologically, there are patches of inflammation …