As the details of the chemical transformations in metabolism have become increasingly
clear, and the enzymes catalysing many of the reactions have been characterized, it is …

Biochemical systems theory (BST) is the foundation for a set of analytical andmodeling tools
that facilitate the analysis of dynamic biological systems. This paper depicts major …

There is little doubt that the central areas of traditional biochemistry (such as metabolism,
metabolic regulation and enzymology) are currently unfashionable and generally regarded …

抄録< jats: p> The behavior of a chemical system is affected by many physicochemical
parameters. The sensitivity of the system's behavior to changes in parameters is known as …

Multi-component signal transduction pathways and gene regulatory circuits underpin
integrated cellular responses to perturbations. A recurring set of network motifs serve as the …

We show how the phenomena of genetic dominance, overdominance, additivity, and
epistasis are generic features of simple diploid gene regulatory networks. These regulatory …

Existing, qualitative notions with respect to the way in which enzyme properties control
metabolism are discussed in the light of the control analysis developed by H. Kacser and JA …

2. Substrate carriers 3. Cytochrome bc~ segment 4. Cytochrome oxidase 5. P, transporter 6.
Substrate dehydrogenases 7. ATP-synthetase 8. Ca2+-transporter 9. Pyridine nucleotide …

Publisher Summary This chapter describes the basic methods of complex biochemical
systems. The phenomenon of regulation has become so familiar that it is easy to overlook …

We have extended Metabolic control Theory to include cascades consisting of several
modules controlling each other solely via regulatory effects. We derive several theorems that …