The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Osteopontin (OPN), a secreted phosphoprotein, is a member of the small integrin-binding
ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many …

Haematopoietic ageing is marked by a loss of regenerative capacity and skewed
differentiation from haematopoietic stem cells (HSCs), leading to impaired blood production …

Aging of hematopoietic stem cells (HSCs) is associated with a decline in their regenerative
capacity and multilineage differentiation potential, contributing to the development of blood …

Hematopoietic stem cell (HSC) self-renewal and aging are tightly regulated by paracrine
factors from the bone marrow niche. However, whether HSC rejuvenation could be achieved …

Hematopoietic stem cells (HSCs), which govern the production of all blood lineages,
transition through a series of functional states characterized by expansion during fetal …

Adult tissue stem cells have a pivotal role in tissue maintenance and regeneration
throughout the lifespan of multicellular organisms. Loss of tissue homeostasis during post …

Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during
embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and …

Hematopoietic stem cells (HSC) sustain blood production over the entire life-span of an
organism. It is of extreme importance that these cells maintain self-renewal and …

Hematopoietic stem cell (HSC) aging was originally thought to be essentially an HSC-
autonomous process, which is the focus of another review in the same issue of …