Aberrant production of the prototypical type 2 cytokines, interleukin (IL)-4 and IL-13 has long
been associated with the pathogenesis of allergic disorders. Despite tremendous scientific …

Delirium is a neurobehavioral syndrome caused by dysregulation of neuronal activity
secondary to systemic disturbances. Over time, a number of theories have been proposed in …

INTRODUCTION The lung, with its vast surface area, senses and responds to signals in
inhaled air. Aberrant interactions between the lung and the environment underlie many …

The development of whole-body imaging at single-cell resolution enables system-level
approaches to studying cellular circuits in organisms. Previous clearing methods focused on …

Abstract Changes in the human gastrointestinal microbiome are associated with several
diseases. To infer causality, experiments in representative models are essential, but widely …

Taurine is often referred to as a semi‐essential amino acid as newborn mammals have a
limited ability to synthesize taurine and have to rely on dietary supply. Taurine is not thought …

Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths
in 2019. The disease is characterized by chronic airway inflammation, reversible …

Hereditary spastic paraplegia comprises a wide and heterogeneous group of inherited
neurodegenerative and neurodevelopmental disorders resulting from primary retrograde …

GABA (γ-aminobutyric acid) is a nonprotein amino acid and naturally occurs in
microorganisms, plants, and animals. GABA is synthesized prominently via GABA shunt …

Mucous cell metaplasia is induced in response to harmful insults and provides front-line
protection to clear the airway of toxic substances and cellular debris. In chronic airway …