Lateral thinking in syndromic congenital cardiovascular disease
Syndromic birth defects are rare diseases that can present with seemingly pleiotropic
comorbidities. Prime examples are rare congenital heart and cardiovascular anomalies that …
comorbidities. Prime examples are rare congenital heart and cardiovascular anomalies that …
[HTML][HTML] Role of Genetic Variation in Transcriptional Regulatory Elements in Heart Rhythm
Genetic predisposition to cardiac arrhythmias has been a field of intense investigation.
Research initially focused on rare hereditary arrhythmias, but over the last two decades, the …
Research initially focused on rare hereditary arrhythmias, but over the last two decades, the …
[HTML][HTML] Global chromatin landscapes identify candidate noncoding modifiers of cardiac rhythm
S Bhattacharyya, RK Kollipara… - The Journal of …, 2023 - Am Soc Clin Investig
Comprehensive cis-regulatory landscapes are essential for accurate enhancer prediction
and disease variant mapping. Although cis-regulatory element (CRE) resources exist for …
and disease variant mapping. Although cis-regulatory element (CRE) resources exist for …
Identification and characterization of Hand2 upstream genomic enhancers active in developing stomach and limbs
CA Ferguson, BA Firulli, M Zoia… - Developmental …, 2024 - Wiley Online Library
Background The bHLH transcription factor HAND2 plays important roles in the development
of the embryonic heart, face, limbs, and sympathetic and enteric nervous systems. To define …
of the embryonic heart, face, limbs, and sympathetic and enteric nervous systems. To define …
Dysregulations in Cardiogenic Mechanisms by TGF-beta and Angiotensin II in Cardiac Remodeling Post-Ischemic Injury: a systematic review
O Shafi, K Zahra, HH Shah - medRxiv, 2024 - medrxiv.org
Objective The objective of this study is to look into how TGF-beta and Angiotensin II disrupt
cardiogenic regulators (Isl1, Brg1/Baf60-Smarcd3 complex, Nkx2-5, GATA4, Tbx5, Mef2c …
cardiogenic regulators (Isl1, Brg1/Baf60-Smarcd3 complex, Nkx2-5, GATA4, Tbx5, Mef2c …