Cell senescence is broadly defined as the physiological program of terminal growth arrest,
which can be triggered by alterations of telomeres or by different forms of stress. Neoplastic …

Innate or acquired resistance to cancer therapeutics remains an important area of
biomedical investigation that has clear ramifications for improving cancer specific death …

Background ODM-201 is a novel androgen receptor (AR) inhibitor designed to block the
growth of prostate cancer cells through high-affinity binding to the AR and inhibition of AR …

Background Cabazitaxel, abiraterone acetate (AA), and enzalutamide have been approved
for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) …

BACKGROUND Advanced glycation end products (AGE) are produced with normal aging.
Recently, some reports indicated that the interaction between AGE and the cognate receptor …

Prostate cancer progression and the development of androgen-independent prostate cancer
have been largely related to a number of genetic abnormality that affect not only the …

Molecular markers have the potential to serve not only as prognostic factors but may be
targets for new therapeutic strategies and predictors of response in a range of cancers …

Makorin Ring Finger Protein 1 (MKRN1) is a transcriptional co‐regulator and an E3 ligase.
Here, we show that MKRN1 simultaneously functions as a differentially negative regulator of …

Purpose Orteronel (TAK-700) is an investigational, nonsteroidal, reversible, selective 17, 20-
lyase inhibitor. This study examined orteronel in patients with metastatic castration-resistant …

Overcoming drug-resistance is a big challenge to improve the survival of patients with
epithelial ovarian cancer (EOC). In this study, we investigated the effect of chloroquine (CQ) …