One way to preserve a rare book is to lock it away from all potential sources of damage. Of
course, an inaccessible book is also of little use, and the paper and ink will continue to …

Abstract Poly (ADP-ribose)(PAR) polymerase-1 (PARP-1) acts as a DNA damage sensor. It
recognizes DNA damage and facilitates DNA repair by recruiting DNA repair machinery to …

Iron is an essential redox element that functions as a cofactor in many metabolic pathways.
Critical enzymes in DNA metabolism, including multiple DNA repair enzymes (helicases …

Accurate processing of stalled or damaged DNA replication forks is paramount to genomic
integrity and recent work points to replication fork reversal and restart as a central …

Activation of the ATR kinase following perturbations to DNA replication relies on a complex
mechanism involving ATR recruitment to RPA-coated single-stranded DNA via its binding …

The ATR checkpoint kinase coordinates cellular responses to DNA replication stress.
Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only …

Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA
damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired …

Eukaryotic cells activate the S-phase checkpoint in response to a variety of events affecting
the progression of replication forks, collectively referred to as replication stress. This …

DNA2 nuclease/helicase is a structure-specific nuclease, 5′-to-3′ helicase, and DNA-
dependent ATPase. It is involved in multiple DNA metabolic pathways, including Okazaki …

ETAA1 (Ewing tumor-associated antigen 1), also known as ETAA16, was identified as a
tumor-specific antigen in the Ewing family of tumors. However, the biological function of this …