Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment

V Rajeev, YL Chai, L Poh, S Selvaraji, DY Fann… - Acta neuropathologica …, 2023 - Springer
Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related
to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically …

Imaging retina to study dementia and stroke

CY Cheung, MK Ikram, C Chen, TY Wong - Progress in retinal and eye …, 2017 - Elsevier
With increase in life expectancy, the number of persons suffering from common age-related
brain diseases, including neurodegenerative (eg, dementia) and cerebrovascular (eg …

Blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of Alzheimer's disease: a focused review on recent advances

JR Chong, NJ Ashton, TK Karikari, T Tanaka… - Journal of Neurology …, 2021 - jnnp.bmj.com
Discovery and development of clinically useful biomarkers for Alzheimer's disease (AD) and
related dementias have been the focus of recent research efforts. While cerebrospinal fluid …

The mortality and the risk of aspiration pneumonia related with dysphagia in stroke patients

MC Feng, YC Lin, YH Chang, CH Chen… - Journal of Stroke and …, 2019 - Elsevier
Background: Dysphagia may result in poor outcomes in stroke patients due to aspiration
pneumonia and malnutrition. Goal: The aim of the study was to investigate aspiration …

Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761®

N Kandiah, PA Ong, T Yuda, LL Ng… - CNS neuroscience & …, 2019 - Wiley Online Library
Abstract Background The Ginkgo biloba special extract, EGb 761® has been widely used in
the treatment of neuropsychiatric disorders, including Alzheimer's disease (AD). Methods To …

Low plasma ergothioneine levels are associated with neurodegeneration and cerebrovascular disease in dementia

LY Wu, IK Cheah, JR Chong, YL Chai, JY Tan… - Free Radical Biology …, 2021 - Elsevier
Ergothioneine (ET) is a dietary amino-thione with strong antioxidant and cytoprotective
properties and has possible therapeutic potential for neurodegenerative and vascular …

Challenges in the practical implementation of blood biomarkers for Alzheimer's disease

M Schöll, IMW Verberk, M Del Campo… - The Lancet Healthy …, 2024 - thelancet.com
Blood biomarkers have emerged as accessible, cost-effective, and highly promising tools for
advancing the diagnostics of Alzheimer's disease. However, transitioning from cerebrospinal …

Brain atrophy and white matter hyperintensities are independently associated with plasma neurofilament light chain in an Asian cohort of cognitively impaired patients …

JR Chong, S Hilal, NJ Ashton… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Plasma neurofilament light chain (NfL) is a potential biomarker for
neurodegeneration in Alzheimer's disease (AD), ischemic stroke, and non‐dementia cohorts …

Plasma P‐tau181 to Aβ42 ratio is associated with brain amyloid burden and hippocampal atrophy in an Asian cohort of Alzheimer's disease patients with concomitant …

JR Chong, NJ Ashton, TK Karikari… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction There is increasing evidence that phosphorylated tau (P‐tau181) is a specific
biomarker for Alzheimer's disease (AD) pathology, but its potential utility in non‐White …

Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer's disease with and without …

F Ji, O Pasternak, S Liu, YM Loke, BL Choo… - Alzheimer's Research & …, 2017 - Springer
Background Mixed vascular and neurodegenerative dementia, such as Alzheimer's disease
(AD) with concomitant cerebrovascular disease, has emerged as the leading cause of age …