ATP-Dependent Steps in Peroxisomal Protein Import

HW Platta, J Jeske, N Schmidt… - Annual Review of …, 2024 - annualreviews.org
Peroxisomes are organelles that play a central role in lipid metabolism and cellular redox
homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal …

Peroxisomal dynamics

HW Platta, R Erdmann - Trends in cell biology, 2007 - cell.com
Peroxisomes are a dynamic compartment in almost all eukaryotic cells and have diverse
metabolic roles in response to environmental changes and cellular demands. The …

Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes

K Shen, RK Huang, EJ Brignole, KJ Condon… - Nature, 2018 - nature.com
Nutrients, such as amino acids and glucose, signal through the Rag GTPases to activate
mTORC1. The GATOR1 protein complex—comprising DEPDC5, NPRL2 and NPRL3 …

Origin and evolution of the peroxisomal proteome

T Gabaldón, B Snel, F Zimmeren, W Hemrika, H Tabak… - Biology Direct, 2006 - Springer
Background Peroxisomes are ubiquitous eukaryotic organelles involved in various oxidative
reactions. Their enzymatic content varies between species, but the presence of common …

VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death

MA Gitcho, J Strider, D Carter… - Journal of Biological …, 2009 - ASBMB
Frontotemporal lobar degeneration (FTLD) with inclusion body myopathy and Paget disease
of bone is a rare, autosomal dominant disorder caused by mutations in the VCP (valosin …

Determinants of peroxisome membrane dynamics

RE Carmichael, M Schrader - Frontiers in Physiology, 2022 - frontiersin.org
Organelles within the cell are highly dynamic entities, requiring dramatic morphological
changes to support their function and maintenance. As a result, organelle membranes are …

Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts

M Nordgren, T Francisco, C Lismont, L Hennebel… - Autophagy, 2015 - Taylor & Francis
Peroxisomes are ubiquitous cell organelles essential for human health. To maintain a
healthy cellular environment, dysfunctional and superfluous peroxisomes need to be …

[HTML][HTML] Uniqueness of the mechanism of protein import into the peroxisome matrix: transport of folded, co-factor-bound and oligomeric proteins by shuttling receptors

S Léon, JM Goodman, S Subramani - Biochimica et Biophysica Acta (BBA) …, 2006 - Elsevier
Based on earlier suggestions that peroxisomes may have arisen from endosymbionts that
later lost their DNA, it was expected that protein transport into this organelle would have …

Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy

NB Blok, D Tan, RYR Wang… - Proceedings of the …, 2015 - National Acad Sciences
Members of the AAA family of ATPases assemble into hexameric double rings and perform
vital functions, yet their molecular mechanisms remain poorly understood. Here, we report …

Insights into the structure and function of the Pex1/Pex6 AAA-ATPase in peroxisome homeostasis

RM Judy, CJ Sheedy, BM Gardner - Cells, 2022 - mdpi.com
The AAA-ATPases Pex1 and Pex6 are required for the formation and maintenance of
peroxisomes, membrane-bound organelles that harbor enzymes for specialized metabolism …