ATP-Dependent Steps in Peroxisomal Protein Import
HW Platta, J Jeske, N Schmidt… - Annual Review of …, 2024 - annualreviews.org
Peroxisomes are organelles that play a central role in lipid metabolism and cellular redox
homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal …
homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal …
Peroxisomal dynamics
HW Platta, R Erdmann - Trends in cell biology, 2007 - cell.com
Peroxisomes are a dynamic compartment in almost all eukaryotic cells and have diverse
metabolic roles in response to environmental changes and cellular demands. The …
metabolic roles in response to environmental changes and cellular demands. The …
Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes
Nutrients, such as amino acids and glucose, signal through the Rag GTPases to activate
mTORC1. The GATOR1 protein complex—comprising DEPDC5, NPRL2 and NPRL3 …
mTORC1. The GATOR1 protein complex—comprising DEPDC5, NPRL2 and NPRL3 …
Origin and evolution of the peroxisomal proteome
T Gabaldón, B Snel, F Zimmeren, W Hemrika, H Tabak… - Biology Direct, 2006 - Springer
Background Peroxisomes are ubiquitous eukaryotic organelles involved in various oxidative
reactions. Their enzymatic content varies between species, but the presence of common …
reactions. Their enzymatic content varies between species, but the presence of common …
VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death
MA Gitcho, J Strider, D Carter… - Journal of Biological …, 2009 - ASBMB
Frontotemporal lobar degeneration (FTLD) with inclusion body myopathy and Paget disease
of bone is a rare, autosomal dominant disorder caused by mutations in the VCP (valosin …
of bone is a rare, autosomal dominant disorder caused by mutations in the VCP (valosin …
Determinants of peroxisome membrane dynamics
RE Carmichael, M Schrader - Frontiers in Physiology, 2022 - frontiersin.org
Organelles within the cell are highly dynamic entities, requiring dramatic morphological
changes to support their function and maintenance. As a result, organelle membranes are …
changes to support their function and maintenance. As a result, organelle membranes are …
Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts
M Nordgren, T Francisco, C Lismont, L Hennebel… - Autophagy, 2015 - Taylor & Francis
Peroxisomes are ubiquitous cell organelles essential for human health. To maintain a
healthy cellular environment, dysfunctional and superfluous peroxisomes need to be …
healthy cellular environment, dysfunctional and superfluous peroxisomes need to be …
[HTML][HTML] Uniqueness of the mechanism of protein import into the peroxisome matrix: transport of folded, co-factor-bound and oligomeric proteins by shuttling receptors
S Léon, JM Goodman, S Subramani - Biochimica et Biophysica Acta (BBA) …, 2006 - Elsevier
Based on earlier suggestions that peroxisomes may have arisen from endosymbionts that
later lost their DNA, it was expected that protein transport into this organelle would have …
later lost their DNA, it was expected that protein transport into this organelle would have …
Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy
Members of the AAA family of ATPases assemble into hexameric double rings and perform
vital functions, yet their molecular mechanisms remain poorly understood. Here, we report …
vital functions, yet their molecular mechanisms remain poorly understood. Here, we report …
Insights into the structure and function of the Pex1/Pex6 AAA-ATPase in peroxisome homeostasis
RM Judy, CJ Sheedy, BM Gardner - Cells, 2022 - mdpi.com
The AAA-ATPases Pex1 and Pex6 are required for the formation and maintenance of
peroxisomes, membrane-bound organelles that harbor enzymes for specialized metabolism …
peroxisomes, membrane-bound organelles that harbor enzymes for specialized metabolism …