[HTML][HTML] Parsing the role of PPARs in macrophage processes
Cells are richly equipped with nuclear receptors, which act as ligand-regulated transcription
factors. Peroxisome proliferator activated receptors (PPARs), members of the nuclear …
factors. Peroxisome proliferator activated receptors (PPARs), members of the nuclear …
The many ways tissue phagocytes respond to dying cells
JM Blander - Immunological reviews, 2017 - Wiley Online Library
Apoptosis is an important component of normal tissue physiology, and the prompt removal of
apoptotic cells is equally essential to avoid the undesirable consequences of their …
apoptotic cells is equally essential to avoid the undesirable consequences of their …
SCFAs alleviated steatosis and inflammation in mice with NASH induced by MCD
M Deng, F Qu, L Chen, C Liu, M Zhang… - Journal of …, 2020 - joe.bioscientifica.com
This study aimed to assess the effects of three major SCFAs (acetate, propionate, and
butyrate) on NASH phenotype in mice. C57BL/6 mice were fed a methionine-and choline …
butyrate) on NASH phenotype in mice. C57BL/6 mice were fed a methionine-and choline …
Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs
Recognition and removal of apoptotic cells by professional phagocytes, including dendritic
cells and macrophages, preserves immune self-tolerance and prevents chronic …
cells and macrophages, preserves immune self-tolerance and prevents chronic …
Endothelial PFKFB3 plays a critical role in angiogenesis
Y Xu, X An, X Guo, TG Habtetsion, Y Wang… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Vascular cells, particularly endothelial cells, adopt aerobic glycolysis to generate
energy to support cellular functions. The effect of endothelial glycolysis on angiogenesis …
energy to support cellular functions. The effect of endothelial glycolysis on angiogenesis …
Indole alleviates diet‐induced hepatic steatosis and inflammation in a manner involving myeloid cell 6‐Phosphofructo‐2‐kinase/Fructose‐2, 6‐Biphosphatase 3
Background and Aims Indole is a microbiota metabolite that exerts anti‐inflammatory
responses. However, the relevance of indole to human non‐alcoholic fatty liver disease …
responses. However, the relevance of indole to human non‐alcoholic fatty liver disease …
[HTML][HTML] Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity
Non-alcoholic fatty liver disease (NAFLD) is closely associated with obesity and insulin
resistance. To better understand the pathophysiology of obesity-associated NAFLD, the …
resistance. To better understand the pathophysiology of obesity-associated NAFLD, the …
Diet complexity and estrogen receptor β status affect the composition of the murine intestinal microbiota
R Menon, SE Watson, LN Thomas… - Applied and …, 2013 - Am Soc Microbiol
Intestinal microbial dysbiosis contributes to the dysmetabolism of luminal factors, including
steroid hormones (sterones) that affect the development of chronic gastrointestinal …
steroid hormones (sterones) that affect the development of chronic gastrointestinal …
Risk of cirrhosis and hepatocellular cancer in patients with NAFLD and normal liver enzymes
Background and Aims The long‐term risk of disease for patients with nonalcoholic fatty liver
disease (NAFLD) in the absence of elevated enzymes is unclear. We conducted a …
disease (NAFLD) in the absence of elevated enzymes is unclear. We conducted a …
[HTML][HTML] Berberine ameliorates hepatic steatosis and suppresses liver and adipose tissue inflammation in mice with diet-induced obesity
Increasing evidence demonstrates that berberine (BBR) is beneficial for obesity-associated
non-alcoholic fatty liver disease (NAFLD). However, it remains to be elucidated how BBR …
non-alcoholic fatty liver disease (NAFLD). However, it remains to be elucidated how BBR …