It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …

Adenosine is an endogenous nucleoside that modulates many physiological processes. Its
actions are mediated by interaction with specific cell membrane receptors. Four subtypes of …

Despite this effort, a widely accepted and satisfying molecular explanation for LTP has not
yet been discovered or, at least, been generally accepted. Rather, at least to outsiders, it …

The purine nucleoside adenosine is consensually identified as a major local regulator of
tissue function especially when energy supply fails to meet cellular energy demand. Due to …

Numerous studies have consistently shown that agonist stimulation of adenosine A1
receptors results in a significant reduction of morbidity and mortality associated with global …

Adenosine is a naturally occurring nucleoside present ubiquitously throughout the body as a
metabolic intermediate. Besides its metabolic role within the cells, adenosine is released …

Adenosine receptors in the central nervous system have been implicated in the modulation
of different behavioural patterns and cognitive functions although the specific role of A2A …

The present experiment was designed to examine the role of adenosine in spatial working
and reference memory in rats using an 8-arm radial maze task which requires the integrity of …

Synaptic plasticity mechanisms, ie the sequence of events that underlies persistent changes
in synaptic strength as a consequence of transient alteration in neuronal firing, are greatly …

The nucleus accumbens is considered to be critically involved in the control of complex
motivated behaviors. By modulating its glutamatergic excitatory input, mesolimbic …