The multifunctional protein HMGB1: 50 years of discovery

D Tang, R Kang, HJ Zeh, MT Lotze - Nature Reviews Immunology, 2023 - nature.com
Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin,
HMGB1 is now known to regulate diverse biological processes depending on its subcellular …

Programmed cell death tunes tumor immunity

J Liu, M Hong, Y Li, D Chen, Y Wu, Y Hu - Frontiers in immunology, 2022 - frontiersin.org
The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …

Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma

DWH Ho, YM Tsui, LK Chan, KMF Sze, X Zhang… - Nature …, 2021 - nature.com
Interaction between tumor cells and immune cells in the tumor microenvironment is
important in cancer development. Immune cells interact with the tumor cells to shape this …

New insights into the immune functions of complement

ES Reis, DC Mastellos, G Hajishengallis… - Nature Reviews …, 2019 - nature.com
The recognition of microbial or danger-associated molecular patterns by complement
proteins initiates a cascade of events that culminates in the activation of surface complement …

Aging, melatonin, and the pro-and anti-inflammatory networks

R Hardeland - International journal of molecular sciences, 2019 - mdpi.com
Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …

Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation

N Niyonzima, J Rahman, N Kunz, EE West… - Science …, 2021 - science.org
While serum-circulating complement destroys invading pathogens, intracellularly active
complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic …

C1q+ macrophages: passengers or drivers of cancer progression

M Revel, C Sautès-Fridman, WH Fridman… - Trends in Cancer, 2022 - cell.com
The omics era made possible the quest for efficient markers for cancer progression and
revealed that macrophage populations are much more complex than just the M1/M2 …

High mobility group box 1 (HMGB1): a pivotal regulator of hematopoietic malignancies

S Yuan, Z Liu, Z Xu, J Liu, J Zhang - Journal of Hematology & Oncology, 2020 - Springer
High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein that has
been widely reported to play a pivotal role in the pathogenesis of hematopoietic …

Extracellular HMGB1 as a therapeutic target in inflammatory diseases

U Andersson, H Yang, H Harris - Expert opinion on therapeutic …, 2018 - Taylor & Francis
Introduction: High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that
promotes inflammation when released extracellularly after cellular activation, stress …

Standardized protocols for differentiation of THP-1 cells to macrophages with distinct M (IFNγ+ LPS), M (IL-4) and M (IL-10) phenotypes

EW Baxter, AE Graham, NA Re, IM Carr… - Journal of …, 2020 - Elsevier
In vitro models of differing macrophage functions are useful since human monocyte–derived
macrophages are short–lived, finite and vary from donor to donor. Published protocols using …