Coccidioidomycosis is the endemic mycosis caused by the fungal pathogens Coccidioides
immitis and C. posadasii. This review is a summary of the recent advances that have been …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• CYP2C19 polymorphisms may have
clinical consequences in relation to drugs extensively metabolized by the enzyme.• Recently …

Background—The cytochrome P450 (CYP) 2C19 isoenzyme plays an important role in
clopidogrel metabolization. A recently explored CYP2C19* 17 allelic variant has been linked …

Despite initial enthusiasm, 1, 2, 3 the use of pharmacogenetics has remained limited to
investigation in only a few clinical fields such as oncology and psychiatry. 4, 5, 6, 7, 8 The …

Background. Recommended oral voriconazole (VRC) doses are lower than intravenous
doses. Because plasma concentrations impact efficacy and safety of therapy, optimizing …

Background During an infection or inflammation, several drug-metabolizing enzymes in the
liver are down-regulated, including cytochrome P450 iso-enzymes. Since voriconazole is …

Introduction: Therapeutic drug monitoring (TDM) has been shown to optimize the
management of invasive fungal infections (IFIs), particularly for select antifungal agents with …

Triazole and imidazole antifungal agents inhibit metabolism of vincristine, leading to excess
vinca alkaloid exposure and severe neurotoxicity. Recent reports of debilitating interactions …

Since its approval by the US Food and Drug Administration in 2002, voriconazole has
become a key component in the successful treatment of many invasive fungal infections …

Responses to drugs and pharmacological treatments differ considerably between
individuals. Importantly, only 50%–75% of patients have been shown to react adequately to …