The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …

Twenty-five years ago, we reported that agonist anti-CD137 monoclonal antibodies
eradicated transplanted mouse tumors because of enhanced CD8+ T-cell antitumor …

We report the updated classification of Inborn Errors of Immunity/Primary
Immunodeficiencies, compiled by the International Union of Immunological Societies Expert …

Primary immunodeficiencies (PIDs) provide researchers with unique models to understand
in vivo immune responses in general and immunity to infections in particular. In humans …

Biallelic mutations in the genes encoding CD27 or its ligand CD70 underlie inborn errors of
immunity (IEIs) characterized predominantly by Epstein-Barr virus (EBV)-associated immune …

Primary immune regulatory disorders (PIRD) are associated with autoimmunity,
autoinflammation and/or dysregulation of lymphocyte homeostasis. Autoimmune …

Epstein-Barr virus (EBV) is an enigma; on one hand, it infects and persists in latent form in
the vast majority of the global population, causing relatively benign disease in otherwise …

Abstract CD137 (4-1BB; TNFSR9) is an activation-induced surface receptor that through
costimulation effects provide antigen-primed T cells with augmented survival, proliferation …

It is important to recognize the broad clinical manifestations of PIRD as patients may have
symptoms atypical of classical 'immunodeficiency'. Because of their diverse immune …

Infections with any of the nine human herpes viruses (HHV) can be asymptomatic or life-
threatening. The study of patients with severe diseases caused by HHVs, in the absence of …