Lipids are abundant and play essential roles in human health and disease. The main
functions of lipids are building blocks for membrane biogenesis. However, lipids are also …

Primary sensory afferents and their neighboring host-defense cells are a rich source of lipid-
derived mediators that contribute to the sensation of pain caused by tissue damage and …

Neuropathic pain is a major, intractable clinical problem and its pathophysiology is not well
understood. Although recent gene expression profiling studies have enabled the …

Background: Marijuana extracts (cannabinoids) have been used for several millennia for
pain treatment. Regarding the site of action, cannabinoids are highly promiscuous …

The therapeutic potential of Cannabis sativa has been recognized since ancient times.
Phytocannabinoids, endocannabinoids and synthetic cannabinoids activate two major G …

Lysophosphatidylinositols (LPIs) are membrane constituents that alter the properties of said
membranes. However, recent data showing that the once orphan receptor, GPR55, can act …

Introduction: Current pharmacotherapeutics for neuropathic pain offer only symptomatic
relief without treating the underlying pathophysiology. Additionally, they are associated with …

Multiple Sclerosis (MuS) is a disease caused due to an autoimmune attack against myelin
components in which non proteic mediators may play a role. Recent research in …

Alzheimer's disease (AD) is a neurodegenerative disorder which accounts for 60–70% of the
50 million worldwide cases of dementia and is characterised by cognitive impairments …

G protein-coupled receptors (GPCRs) comprise a large number of receptors. Orphan
GPCRs are divided into six families. These groups contain orphan receptors for which the …