Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria

JG Beeson, DR Drew, MJ Boyle, G Feng… - FEMS microbiology …, 2016 - academic.oup.com
Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum
accounting for the majority of malaria, and P. vivax being a second important cause …

[HTML][HTML] Invasion of red blood cells by malaria parasites

AF Cowman, BS Crabb - Cell, 2006 - cell.com
The malaria parasite is the most important member of the Apicomplexa, a large and highly
successful phylum of intracellular parasites. Invasion of host cells allows apicomplexan …

[HTML][HTML] Revealing the Sequence and Resulting Cellular Morphology of Receptor-Ligand Interactions during Plasmodium falciparum Invasion of Erythrocytes

GE Weiss, PR Gilson, T Taechalertpaisarn… - PLoS …, 2015 - journals.plos.org
During blood stage Plasmodium falciparum infection, merozoites invade uninfected
erythrocytes via a complex, multistep process involving a series of distinct receptor-ligand …

Immune effector mechanisms in malaria

K Marsh, S Kinyanjui - Parasite immunology, 2006 - Wiley Online Library
That humans in endemic areas become immune to malaria offers encouragement to the
idea of developing protective vaccines. However natural immunity is relatively inefficient …

[HTML][HTML] The Relationship between Anti-merozoite Antibodies and Incidence of Plasmodium falciparum Malaria: A Systematic Review and Meta-analysis

FJI Fowkes, JS Richards, JA Simpson… - PLoS medicine, 2010 - journals.plos.org
Background One of the criteria to objectively prioritize merozoite antigens for malaria
vaccine development is the demonstration that naturally acquired antibodies are associated …

Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development

MJ Boyle, DW Wilson, JS Richards… - Proceedings of the …, 2010 - National Acad Sciences
During blood-stage infection by Plasmodium falciparum, merozoites invade RBCs. Currently
there is limited knowledge of cellular and molecular invasion events, and no established …

[HTML][HTML] Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum* S

PR Gilson, T Nebl, D Vukcevic, RL Moritz… - Molecular & cellular …, 2006 - ASBMB
Most proteins that coat the surface of the extracellular forms of the human malaria parasite
Plasmodium falciparum are attached to the plasma membrane via …

[HTML][HTML] Progress and challenges for malaria vaccines

TL Richie, A Saul - Nature, 2002 - nature.com
Malaria causes much physical and economic hardship in tropical regions, particularly in
communities where medical care is rudimentary. Should a vaccine be developed, it is the …

The future for blood‐stage vaccines against malaria

JS Richards, JG Beeson - Immunology and cell biology, 2009 - Wiley Online Library
Malaria is a leading cause of mortality and morbidity globally, and effective vaccines are
urgently needed. Malaria vaccine approaches can be broadly grouped as pre‐erythrocytic …

Band 3 is a host receptor binding merozoite surface protein 1 during the Plasmodium falciparum invasion of erythrocytes

VK Goel, X Li, H Chen, SC Liu… - Proceedings of the …, 2003 - National Acad Sciences
We report the molecular identification of a sialic acid-independent host–parasite interaction
in the Plasmodium falciparum malaria parasite invasion of RBCs. Two nonglycosylated …