Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of
stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of …

Thrombomodulin (TM) is an integral component of a multimolecular system, localized
primarily to the vascular endothelium, that integrates crucial biological processes and …

Thrombin is a multifunctional serine protease generated in injured cells. The generation of
thrombin in coagulation plays a central role in the functioning of haemostasis. The last …

Controlled proteolysis underlies a vast diversity of protective and regulatory processes that
are of key importance to cell fate. The unique molecular architecture of the widely conserved …

Vascular endothelial growth factor (VEGF) is a critical mediator of blood vessel formation
during development and in pathological conditions. In this study, we demonstrate that VEGF …

The goal is to provide an extensive review of the physiologic role of thrombomodulin (TM) in
maintaining vascular homeostasis, with a focus on its anti-inflammatory properties. Data …

The hierarchical self-assembly of rationally designed synthetic peptides into β-sheet tapes,
ribbons, fibrils, and fibers opens up potentially useful routes to soft− solidlike materials such …

Hemostasis and fibrinolysis, the biological processes that maintain proper blood flow, are
the consequence of a complex series of cascading enzymatic reactions. Serine proteases …

Thrombin is a Na+-activated, allosteric serine protease that plays opposing functional roles
in blood coagulation. Binding of Na+ is the major driving force behind the procoagulant …