High-throughput mass spectrometry imaging of biological systems: Current approaches and future directions

LX Jiang, M Yang, SN Wali, J Laskin - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
In the past two decades, the power of mass spectrometry imaging (MSI) for the label free
spatial mapping of molecules in biological systems has been substantially enhanced by the …

Advances in mass spectrometry for clinical analysis: Data acquisition, interpretation and information integration

H Zhang, Z Ouyang, W Zhang - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Bioinformatics has played an important role in analyzing chemical information acquired
using mass spectrometry (MS) for large numbers of biological samples. Here we review the …

Physics discovery in nanoplasmonic systems via autonomous experiments in scanning transmission electron microscopy

KM Roccapriore, SV Kalinin, M Ziatdinov - Advanced Science, 2022 - Wiley Online Library
Physics‐driven discovery in an autonomous experiment has emerged as a dream
application of machine learning in physical sciences. Here, this work develops and …

Demonstration of an AI-driven workflow for autonomous high-resolution scanning microscopy

S Kandel, T Zhou, AV Babu, Z Di, X Li, X Ma… - Nature …, 2023 - nature.com
Modern scanning microscopes can image materials with up to sub-atomic spatial and sub-
picosecond time resolutions, but these capabilities come with large volumes of data, which …

High-throughput mass spectrometry imaging with dynamic sparse sampling

H Hu, D Helminiak, M Yang, D Unsihuay… - ACS Measurement …, 2022 - ACS Publications
Mass spectrometry imaging (MSI) enables label-free mapping of hundreds of molecules in
biological samples with high sensitivity and unprecedented specificity. Conventional MSI …

Nanospray Desorption Electrospray Ionization Mass Spectrometry Imaging (nano-DESI MSI): A Tutorial Review

M Iqfath, SN Wali, S Amer, E Hernly… - ACS Measurement …, 2024 - ACS Publications
Nanospray desorption electrospray ionization (nano-DESI) is a liquid-based ambient mass
spectrometry imaging (MSI) technique that enables visualization of analyte distributions in …

Enhancing the throughput of FT mass spectrometry imaging using joint compressed sensing and subspace modeling

YR Xie, DC Castro, SS Rubakhin… - Analytical …, 2022 - ACS Publications
Mass spectrometry imaging (MSI) allows for untargeted mapping of the chemical
composition of tissues with attomole detection limits. MSI using Fourier transform (FT)-based …

Multimodal image fusion offers better spatial resolution for mass spectrometry imaging

L Guo, J Zhu, K Wang, KK Cheng, J Xu… - Analytical …, 2023 - ACS Publications
High-resolution reconstruction has attracted increasing research interest in mass
spectrometry imaging (MSI), but it remains a challenging ill-posed problem. In the present …

High-resolution integrated microfluidic probe for mass spectrometry imaging of biological tissues

X Li, H Hu, J Laskin - Analytica Chimica Acta, 2023 - Elsevier
Nanospray desorption electrospray ionization (nano-DESI) is an ambient ionization
technique that enables molecular imaging of biological samples with high spatial resolution …

DeepS: Accelerating 3D Mass Spectrometry Imaging via a Deep Neural Network

D Li, Y Qian, H Yao, W Yu, X Ma - Analytical Chemistry, 2023 - ACS Publications
Mass spectrometry imaging (MSI) is a powerful methodology that enables the visualization
of the spatial distribution of biomolecules, including lipids, peptides, and proteins, from …