THC and CBD: Similarities and differences between siblings

N Stella - Neuron, 2023 - cell.com
Summary Δ 9-tetrahydrocannabinol (THC) and its sibling, cannabidiol (CBD), are produced
by the same Cannabis plant and have similar chemical structures but differ dramatically in …

[HTML][HTML] Acute cannabinoids produce robust anxiety-like and locomotor effects in mice, but long-term consequences are age-and sex-dependent

CR Kasten, Y Zhang, SL Boehm - Frontiers in behavioral …, 2019 - frontiersin.org
The rise in cannabinoid legalization and decriminalization in the US has been paired with
an increase in adolescents that perceive marijuana as a “no risk” drug. However, a …

Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Hippocampus: Cannabidiol Blunts Δ9-Tetrahydrocannabinol-Induced Cognitive Impairment

E Aso, V Fernández-Dueñas, M López-Cano… - Molecular …, 2019 - Springer
At present, clinical interest in the plant-derived cannabinoid compound cannabidiol (CBD) is
rising exponentially, since it displays multiple therapeutic properties. In addition, CBD can …

[HTML][HTML] The dynamic relationship between the glymphatic system, aging, memory, and sleep

KI Voumvourakis, E Sideri, GN Papadimitropoulos… - Biomedicines, 2023 - mdpi.com
The process of memory entails the activation of numerous neural networks and biochemical
pathways throughout the brain. The phenomenon of memory decline in relation to aging has …

[HTML][HTML] Protein kinase C isozymes and autophagy during neurodegenerative disease progression

HN Kaleli, E Ozer, VO Kaya, O Kutlu - Cells, 2020 - mdpi.com
Protein kinase C (PKC) isozymes are members of the Serine/Threonine kinase family
regulating cellular events following activation of membrane bound phospholipids. The …

Serum total cholesterol levels associated with immediate memory performance in patients with chronic schizophrenia

G Zhang, X Ye, X Wang, Y Lin, C Zhu, J Pan, X Yin… - Schizophrenia …, 2023 - Elsevier
Cognitive impairments are common in patients with schizophrenia. Changes in total
cholesterol (TC) may be involved in the development of schizophrenia and associated with …

[HTML][HTML] Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain

A Escudero-Lara, J Argerich, D Cabañero… - Elife, 2020 - elifesciences.org
Endometriosis is a chronic painful disease highly prevalent in women that is defined by
growth of endometrial tissue outside the uterine cavity and lacks adequate treatment …

Neurobiological mechanisms underlying cannabis-induced memory impairment

P Prini, E Zamberletti, C Manenti, M Gabaglio… - European …, 2020 - Elsevier
A growing body of literature suggests that cannabis intake can induce memory loss in
humans and animals. Besides the recreational use, daily cannabis users may also belong to …

Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome

A Navarro-Romero, A Vázquez-Oliver… - Neurobiology of …, 2019 - Elsevier
Intellectual disability is the most limiting hallmark of Down syndrome, for which there is no
gold-standard clinical treatment yet. The endocannabinoid system is a widespread …

Receptor mechanisms underlying the CNS effects of cannabinoids: CB1 receptor and beyond

B Hempel, ZX Xi - Advances in Pharmacology, 2022 - Elsevier
Cannabis legalization continues to progress in many US states and other countries. Δ 9-
tetrahydrocannabinol (Δ 9-THC) is the major psychoactive constituent in cannabis …