Cryogenic electron microscopy (cryo-EM) enables structure determination of
macromolecular objects and their assemblies. Although the techniques have been …

Abstract Knowledge of the three-dimensional structures of proteins and other biological
macromolecules often aids understanding of how they perform complicated tasks in the cell …

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
had a large impact on global health, travel, and economy. Therefore, preventative and …

Vaccine efforts to combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), which is responsible for the current coronavirus disease 2019 (COVID-19) pandemic, are …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is
continuing to disrupt personal lives, global healthcare systems, and economies. Hence …

Conventional immunization strategies will likely be insufficient for the development of a
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …

Adjuvants are central to the efficacy of subunit vaccines. Aluminum hydroxide (alum) is the
most commonly used vaccine adjuvant, yet its adjuvanticity is often weak and mechanisms …

Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine
maturation and cell death. AIM2 and NLRP3 are representative sensor proteins in two major …

Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that
recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts …

The development of native-like HIV-1 envelope (Env) trimer antigens has enabled the
induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 …