[HTML][HTML] APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition

S Naguib, ER Torres, C Lopez-Lee, L Fan, M Bhagwat… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Summary The Christchurch mutation (R136S) on the APOE3 (E3 S/S) gene is associated
with low tau pathology and slowdown of cognitive decline despite the causal PSEN1 …

hiPSC-derived astrocytes from individuals with schizophrenia promote alterations in phagocytosis and chemotaxis of microglial-like cells

PL Cardozo, CY Lee, JPS Lacerda, JS Fahel… - bioRxiv, 2024 - biorxiv.org
Neuroinflammation, particularly astrocyte reactivity, are increasingly linked to schizophrenia
(SCZ). Yet, the crosstalk between astrocytes and microglia in SCZ, especially under pro …